The parent CysLT produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4; potent inducer of bronchoconstriction and enhanced vascular permeability that contributes to the pathogenesis of asthma and acute allergic hypersensitivity

Leukotriene C4 – 50 µg

Brand:
Cayman
CAS:
72025-60-6
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Leukotriene C4 (LTC4) is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets.{781} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity.{538} LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity.{394,396} The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM.{396}  

 

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Description

The parent CysLT produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4; potent inducer of bronchoconstriction and enhanced vascular permeability that contributes to the pathogenesis of asthma and acute allergic hypersensitivity

Formal name: 5S-hydroxy-6R-(S-glutathionyl)-7E,9E,11Z,14Z-eicosatetraenoic acid

Synonyms:  LTC4

Molecular weight: 625.8

CAS: 72025-60-6

Purity: ≥97%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Leukotrienes||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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