An activator of SIRT1

BML-278 – 1 mg

Brand:
Cayman
CAS:
120533-76-8
Storage:
-20
UN-No:
Non-Hazardous - /

BML-278 is an activator of sirtuin 1 (SIRT1) that has an EC150 value (effective concentration able to increase the enzyme by 150%) of 1 µM.{34113} It less potently activates SIRT2 and SIRT3 (EC150s = 25 and 50 µM, respectively).{34113} BML-278 induces hypoacetylation on α-tubulin in U937 cells that are pretreated with SAHA (Item No. 10009929), a histone deacetylase inhibitor. It arrests cell cycling at the G1/S phase, reduces senescence in primary human mesenchymal cells, and significantly increases mitochondrial density in murine C2C12 myoblasts.{34113}  

 

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Description

An activator of SIRT1, SIRT2, and SIRT3 (EC150s = 1, 25, and 50 µM, respectively); arrests cell cycling at the G1/S phase, reduces senescence in primary human mesenchymal cells, and significantly increases mitochondrial density in murine C2C12 myoblasts

Formal name: 1,4-dihydro-4-phenyl-1-(phenylmethyl)-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester

Synonyms: 

Molecular weight: 391.5

CAS: 120533-76-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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