An irreversible inhibitor of chymotrypsin-like proteases that has been shown to affect cell proliferation

Tosyl Phenylalanyl Chloromethyl Ketone – 1 g

Brand:
Cayman
CAS:
402-71-1
Storage:
-20
UN-No:
Non-Hazardous - 3335 / 9

Tosyl phenylalanyl chloromethyl ketone (TPCK) is an irreversible inhibitor of chymotrypsin-like proteases that has been shown to affect cell proliferation, apoptosis, and tumorigenesis.{33079} It can disrupt PDK1 signaling to the AGC kinases, Akt, S6K1, and RSK, as well as MSK1 and MSK2.{33078} TPCK also inhibits superoxide production and suppresses neutrophil respiratory burst.{33080}  

 

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Description

An irreversible inhibitor of chymotrypsin-like proteases that has been shown to affect cell proliferation, apoptosis, and tumorigenesis; disrupts PDK1 signaling to the AGC kinases and also inhibits superoxide production

Formal name: N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-4-methyl-benzenesulfonamide

Synonyms:  Nα-Tosyl-L-Phenylalanine Chloromethyl Ketone|TPCK

Molecular weight: 351.8

CAS: 402-71-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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