An inhibitor of STK33 (IC50 = 14 nM); has 700- and 550-fold selectivity for STK33 over PKA and Aurora B kinase

ML-281 – 5 mg

Brand:
Cayman
CAS:
1404437-62-2
Storage:
-20
UN-No:
Non-Hazardous - /

ML-281 is an inhibitor of the serine/threonine kinase STK33 (IC50 = 14 nM for purified, recombinant STK33), a kinase whose downregulation is toxic to KRAS-dependent cancer cell lines.{40464} It has 700- and 550-fold selectivity for STK33 over PKA and Aurora B kinase, respectively. It is also selective over 81 other kinases in a panel at a concentration of 1 µM, but does inhibit the activity of Fms-like tyrosine kinase (FLT3) and vascular endothelial growth factor receptor 2 (VEGFR2/KDR) by greater than 25%. ML-281 does not decrease viability of KRAS-dependent or KRAS-independent cell lines.  

 

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SKU: 20116 - Category:

Description

An inhibitor of STK33 (IC50 = 14 nM); has 700- and 550-fold selectivity for STK33 over PKA and Aurora B kinase, respectively; selective over 81 other kinases in a panel at a concentration of 1 µM; inhibits FLT3 and VEGFR2/KDR by greater than 25% at a concentration of 1 µM; does not decrease viability of KRAS-dependent or KRAS-independent cell lines

Formal name: N-​[2-​(3,​4-​dihydro-​3-​oxo-​2-​quinoxalinyl)​-​4-​(1-​methylethyl)​phenyl]​-2-​thiophenecarboxamide

Synonyms: 

Molecular weight: 389.5

CAS: 1404437-62-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Signaling

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