An Axl kinase inhibitor; inhibits proliferation of inflammatory breast cancer cells (IC50s = 0.43 and 0.15 µM for SUM149 and KPL-4 cells

SGI-7079 – 25 mg

Brand:
Cayman
CAS:
1239875-86-5
Storage:
-20
UN-No:
De Minimis - 3077 / 9

SGI-7079 is an inhibitor of the receptor tyrosine kinase Axl.{38140} It inhibits proliferation of inflammatory breast cancer cells (IC50s = 0.43 and 0.15 µM for SUM149 and KPL-4 cells, respectively), decreases invasion, and halts the cell cycle in the G1 phase. SGI-7079 synergistically increases the potency of erlotinib (Item No. 10483) on EGFR inhibition.{38139} In a mouse xenograft model of non-small cell lung cancer, SGI-7079 dose-dependently inhibits tumor growth, an effect that is greater when used in combination with erlotinib.  

 

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Description

An Axl kinase inhibitor; inhibits proliferation of inflammatory breast cancer cells (IC50s = 0.43 and 0.15 µM for SUM149 and KPL-4 cells, respectively); synergistically increases the potency of erlotinib on EGFR inhibition; dose-dependently inhibits tumor growth in a mouse xenograft model of non-small cell lung cancer

Formal name: 3-[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-benzeneacetonitrile

Synonyms: 

Molecular weight: 455.5

CAS: 1239875-86-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Signaling

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