A key dihydroxy fatty acid derived from AA through the 5-LO pathway; promotes a number of leukocyte functions including chemotaxis and chemokinesis at subnanomolar concentrations

Leukotriene B4 – 50 µg

Brand:
Cayman
CAS:
71160-24-2
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway.{521,719,948} It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10−10 M), LTB4 causes chemotaxis and chemokinesis in human polymorphonuclear leukocytes.{329} At higher concentrations, (1.0 x 10−7 M), LTB4 leads to neutrophil aggregation and degranulation as well as superoxide anion production.{329,82}  

 

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Description

A key dihydroxy fatty acid derived from AA through the 5-LO pathway; promotes a number of leukocyte functions including chemotaxis and chemokinesis at subnanomolar concentrations

Formal name: 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid

Synonyms:  LTB4

Molecular weight: 336.5

CAS: 71160-24-2

Purity: ≥97%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Leukotrienes||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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