An oxysterol and RORγ and RORγt agonist; activates RORγ- or RORγt-dependent signaling in reporter assays using HEK293T cells expressing the recombinant human receptors (EC50s = 691 and 1

7β,27-dihydroxy Cholesterol – 1 mg

Brand:
Cayman
CAS:
240129-43-5
Storage:
-20
UN-No:
Non-Hazardous - /

7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt.{33003} It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 µM. It increases IL-17A production in Th17-polarized isolated human naïve CD4+ T cells when used at a concentration of 300 nM. 7β,27-dihydroxy Cholesterol (60 mg/kg) increases IL-17A production in isolated mouse γδ T cells stimulated with 12-myristate 13-acetate (PMA; Item No. 10008014) and ionomycin (Item Nos. 10004974 | 11932).  

 

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Description

An oxysterol and RORγ and RORγt agonist; activates RORγ- or RORγt-dependent signaling in reporter assays using HEK293T cells expressing the recombinant human receptors (EC50s = 691 and 1,0451 nM, respectively); selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 µM; increases IL-17A production in Th17-polarized isolated human naïve CD4+ T cells at 300 nM; increases PMA and ionomycin-induced IL-17A production in isolated mouse γδ T cells at 60 mg/kg

Formal name: (3β,7β,25R)-cholest-5-ene-3,7,26-triol

Synonyms:  7β,27-DHC

Molecular weight: 418.7

CAS: 240129-43-5

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|RARs, RORs, & RXRs||Research Area|Immunology & Inflammation|Adaptive Immunity

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