An N-acyl amide that uncouples mitochondrial respiration independent of UCP1 in vitro; decreases body weight and food intake

N-Oleoyl Leucine – 1 mg

Brand:
Cayman
CAS:
136560-76-4
Storage:
-20
UN-No:
De Minimis - 1170 / 3

N-Oleoyl leucine is an N-acyl amide generated by PM20D1 that uncouples mitochondrial respiration independent of uncoupling protein 1 (UCP1) in vitro.{31656} N-Oleoyl leucine (25 mg/kg, i.p.) decreases body weight and food intake, preferentially decreasing fat mass in a diet-induced obesity mouse model. It improves glucose homeostasis in a fasting glucose tolerance test and increases VO2 while slightly decreasing overall locomotor activity.  

 

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Description

An N-acyl amide that uncouples mitochondrial respiration independent of UCP1 in vitro; decreases body weight and food intake, preferentially decreasing fat mass in a diet-induced obesity mouse model; improves glucose homeostasis and increases energy expenditure while slightly decreasing overall locomotor activity

Formal name: N-[(9Z)-1-oxo-9-octadecen-1-yl]-L-leucine

Synonyms: 

Molecular weight: 395.6

CAS: 136560-76-4

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Fatty Amides||Product Type|Biochemicals|Lipids|Octadecanoids||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Research Area|Cell Biology|Mitochondrial Biology||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity

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