An inhibitor of LRRK2 (IC50 = 20.3 nM); also inhibits G2019S

HG-10-102-01 – 1 mg

Brand:
Cayman
CAS:
1351758-81-0
Storage:
-20
UN-No:
De Minimis - 3077 / 9

HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 20.3 nM).{33361} It also inhibits the G2019S, A2016T, and [G2019S+A2016T] mutants of LRRK2 (IC50s = 3.2, 153, and 95.9 nM, respectively).{33361} HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant LRRK2 in cells. When given intraperitoneally, HG-10-102-01 penetrates the blood-brain barrier and inhibits phosphorylation of LRRK2 in the brain as well as the kidney and spleen.{33361}  

 

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SKU: 20049 - Category:

Description

An inhibitor of LRRK2 (IC50 = 20.3 nM); also inhibits G2019S, A2016T, and [G2019S+A2016T] mutants of LRRK2 (IC50s = 3.2, 153, and 95.9 nM, respectively); brain penetrant and inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant LRRK2

Formal name: [4-[[5-chloro-4-(methylamino)-2-pyrimidinyl]amino]-3-methoxyphenyl]-4-morpholinyl-methanone

Synonyms: 

Molecular weight: 377.8

CAS: 1351758-81-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Neuroscience

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