A metabolite of 5-HT in humans that has also been found in plants; an agonist of 5-HT7 receptors (IC50 = 23 pM in a radioligand binding assay); increases intracellular cyclic AMP production in 5-HT7-expressing HEK293 cells (EC50 = 22 nM); inhibits serotonin uptake in HEK293 cells expressing human serotonin transporters (IC50 = 490 nM); elevated urinary levels have been found in patients with schizophrenia

5-hydroxy-Nω-methyl Tryptamine (oxalate) – 500 mg

Brand:
Cayman
CAS:
15558-50-6
Storage:
-20
UN-No:
Non-Hazardous - /

5-hydroxy-Nω-methyl Tryptamine is a metabolite of serotonin (5-HT; Item No. 14332) in humans that has also been found in plants.{48185,31973,42693} It is an agonist of the 5-HT receptor subtype 5-HT7 (IC50 = 23 pM in a radioligand binding assay).{31973} 5-hydroxy-Nω-methyl Tryptamine increases intracellular cyclic AMP production in HEK293 cells expressing 5-HT7 (EC50 = 22 nM). It inhibits serotonin uptake in HEK293 cells expressing human serotonin transporters (IC50 = 490 nM). Elevated levels of urinary 5-hydroxy-Nω-methyl tryptamine have been found in patients with schizophrenia, depression, and epilepsy.{48185}  

 

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Description

A metabolite of 5-HT in humans that has also been found in plants; an agonist of 5-HT7 receptors (IC50 = 23 pM in a radioligand binding assay); increases intracellular cyclic AMP production in 5-HT7-expressing HEK293 cells (EC50 = 22 nM); inhibits serotonin uptake in HEK293 cells expressing human serotonin transporters (IC50 = 490 nM); elevated urinary levels have been found in patients with schizophrenia, depression, and epilepsy

Formal name: 3-[2-(methylamino)ethyl]-1H-indol-5-ol, ethanedioate

Synonyms:  N-methyl Serotonin|N-methyl-5-HT|N-methyl-5-hydroxy Tryptamine

Molecular weight: 280.3

CAS: 15558-50-6

Purity: ≥95%

Formulation: A crystalline solid

Application||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety||Research Area|Neuroscience|Behavioral Neuroscience|Bipolar Disorder||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms||Research Area|Neuroscience|Seizure Disorders

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