A neutral antagonist of the central CB1 receptor (Ki = 8.6 nM); inhibits food consumption in nonfasted mice without affecting motor activity; diminishes REM sleep

ABD459 – 10 mg

Brand:
Cayman
CAS:
1047670-51-8
Storage:
-20
UN-No:
Non-Hazardous - /

ABD459 is a neutral antagonist of the central cannabinoid 1 (CB1) receptor (Ki = 8.6 nM).{32470} It inhibits food consumption in nonfasted mice without affecting motor activity.{32470} ABD459 reduces active food seeking for 5-6 hours after treatment, with no rebound after washout. ABD459 also diminishes rapid eye movement (REM) sleep, with no alterations of wakefulness or non-REM sleep.{32470}  

 

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Description

A neutral antagonist of the central CB1 receptor (Ki = 8.6 nM); inhibits food consumption in nonfasted mice without affecting motor activity; diminishes REM sleep, with no alterations of wakefulness or non-REM sleep

Formal name: [5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl](4-methoxyphenyl)-methanone

Synonyms: 

Molecular weight: 516.2

CAS: 1047670-51-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Neuroscience|Behavioral Neuroscience|Food Intake||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors

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