An orally bioavailable inhibitor of SHP2 (IC50 = 71 nM); blocks the proliferation of receptor tyrosine kinase-driven human cancer cell in vitro and in vivo

SHP099 – 500 µg

Brand:
Cayman
CAS:
1801747-42-1
Storage:
-20
UN-No:
Non-Hazardous - /

SHP099 is an orally bioavailable inhibitor of SHP2, a non-receptor protein tyrosine phosphatase (IC50 = 71 nM).{34164,34163} It stabilizes SHP2 in an auto-inhibited conformation.{34163} SHP099 suppresses signaling through the Ras-ERK pathway and blocks the proliferation of receptor tyrosine kinase-driven human cancer cells in vitro and in vivo.{34163}  

 

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Description

An orally bioavailable inhibitor of SHP2 (IC50 = 71 nM); blocks the proliferation of receptor tyrosine kinase-driven human cancer cell in vitro and in vivo,

Formal name: 6-(4-amino-4-methyl-1-piperidinyl)-3-(2,3-dichlorophenyl)-2-pyrazinamine

Synonyms: 

Molecular weight: 352.3

CAS: 1801747-42-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling||Research Area|Cell Biology|Cell Signaling

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