An inhibitor of MDMX that disrupts MDMX-p53 peptide interaction (EC50 = 4.3 µM); induces apoptosis

SJ 172550 – 1 mg

Brand:
Cayman
CAS:
431979-47-4
Storage:
-20
UN-No:
Non-Hazardous - /

SJ 172550 is an inhibitor of MDMX that disrupts MDMX-p53 peptide interaction with an EC50 value of 4.3 µM.{33300} It forms a covalent, but reversible, cysteine adduct in the MDMX p53-binding domain, locking MDMX into a conformation that prevents binding to p53.{33301} SJ 172550 induces apoptosis, increases p53 target gene expression, and causes p53-dependent cell death in retinoblastoma cells.{33300}  

 

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Description

An inhibitor of MDMX that disrupts MDMX-p53 peptide interaction (EC50 = 4.3 µM); induces apoptosis, increases p53 target gene expression, and causes p53-dependent cell death in retinoblastoma cells

Formal name: 2-[2-chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]-acetic acid, methyl ester

Synonyms:  MDMX Inhibitor II

Molecular weight: 428.9

CAS: 431979-47-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53

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