A potent and selective inhibitor of Glut1 (IC50s = 2

BAY-876 – 25 mg

Brand:
Cayman
CAS:
1799753-84-6
Storage:
-20
UN-No:
Non-Hazardous - /

BAY-876 is a potent and selective inhibitor of glucose transporter 1 (Glut1) with IC50 values of 2, 10,800, 1,670, and 290 nM for Glut1, Glut2, Glut3, and Glut4, respectively, in CHO cells expressing human recombinant receptors.{38214} It shows low metabolic clearance and has high permeability in vitro. In vivo, BAY-876 displays low plasma clearance and high oral bioavailability in rats and dogs.  

 

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SKU: 19961 - Category:

Description

A potent and selective inhibitor of Glut1 (IC50s = 2, 10,800, 1,670, and 290 nM for Glut1-4, respectively); shows low metabolic clearance in multiple cell types and has high permeability in Caco-2 cells; displays low plasma clearance and high oral bioavailability in rats and dogs,

Formal name: N4-[1-[(4-cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide

Synonyms: 

Molecular weight: 496.4

CAS: 1799753-84-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism

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