Description
An inhibitor of Src kinases (IC50s = 50 = 479 nM), as well as KIT, mTOR, PDGFRα, and RET (IC50s = >100 µM for all); completely inhibits Src and FAK phosphorylation at 100 nM; inhibits proliferation of MCF-7 cells (EC50 = 9 nM); reduces levels of activated Src kinase in tumor tissue in an HCT116 mouse xenograft model at 50 mg/kg per day
Formal name: N-[4-[4-amino-1-[2-[4-(dimethylamino)-1-piperidinyl]ethyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-carbamic acid, 1,1-dimethylethyl ester
Synonyms:
Molecular weight: 510.6
CAS: 1914078-41-3
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis
