An inhibitor of Src kinases (IC50s = 50 = 479 nM)

eCF506 – 1 mg

Brand:
Cayman
CAS:
1914078-41-3
Storage:
-20
UN-No:
Non-Hazardous - /

eCF506 is an inhibitor of Src kinases (IC50s = 50 = 479 nM), as well as KIT, mTOR, PDGFRα, and RET (IC50s = >100 µM for all). eCF506 completely inhibits phosphorylation of Src and FAK, a downstream Src substrate, in MCF-7 and MDA-MB-231 cells when used at a concentration of 100 nM. It also inhibits proliferation of MCF-7 cells (EC50 = 9 nM) and induces apoptosis. eCF506 (50 mg/kg per day) reduces levels of activated Src kinase in tumor tissue in an HCT116 mouse xenograft model.  

 

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SKU: 19959 - Category:

Description

An inhibitor of Src kinases (IC50s = 50 = 479 nM), as well as KIT, mTOR, PDGFRα, and RET (IC50s = >100 µM for all); completely inhibits Src and FAK phosphorylation at 100 nM; inhibits proliferation of MCF-7 cells (EC50 = 9 nM); reduces levels of activated Src kinase in tumor tissue in an HCT116 mouse xenograft model at 50 mg/kg per day

Formal name: N-[4-[4-amino-1-[2-[4-(dimethylamino)-1-piperidinyl]ethyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-carbamic acid, 1,1-dimethylethyl ester

Synonyms: 

Molecular weight: 510.6

CAS: 1914078-41-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis

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