A selective inhibitor of TAF1 bromodomain 2 (Kd = 1.8 µM; IC50 = 0.9 µM); synergizes with (+)-JQ1 to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells

CeMMEC1 – 500 µg

Brand:
Cayman
CAS:
440662-09-9
Storage:
-20
UN-No:
Non-Hazardous - /

CeMMEC1 is an N-methylisoquinolinone that inhibits the second bromodomain of TAF1 (Kd = 1.8 µM; IC50 = 0.9 µM).{31547} It does not bind to either the first or second bromodomain of BRD4.{31547} This compound synergizes with (+)-JQ1 (Item No. 11187) to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells.{31547}  

 

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SKU: 19956 - Category:

Description

A selective inhibitor of TAF1 bromodomain 2 (Kd = 1.8 µM; IC50 = 0.9 µM); synergizes with (+)-JQ1 to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells

Formal name: N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-2-methyl-1-oxo-4-isoquinolinecarboxamide

Synonyms: 

Molecular weight: 336.3

CAS: 440662-09-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Chromatin Reader Interactions||Research Area|Epigenetics, Transcription, & Translation|Readers|Bromodomains

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