A reactivator of p53 that restores wild-type p53 signaling by activating p73-dependent apoptosis in mutant p53-expressing colon cancer cells (EC50 = 8.38 µM); induces p53 mutant protein degradation via MDM2-mediated ubiquitination

NSC 59984 – 25 mg

Brand:
Cayman
CAS:
803647-40-7
Storage:
-20
UN-No:
Non-Hazardous - /

NSC 59984 is a reactivator of p53 that restores wild-type p53 signaling by activating p73-dependent apoptosis in mutant p53-expressing colon cancer cells.{31961} It is reported to induce cell death in colon cancer cells (EC50 = 8.38 µM in p53-null HCT116 cells) without evident toxicity toward normal cells.{31961} NSC 59984 has been shown to induce p53 mutant protein degradation via MDM2-mediated ubiquitination.{31961}  

 

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SKU: 19919 - Category:

Description

A reactivator of p53 that restores wild-type p53 signaling by activating p73-dependent apoptosis in mutant p53-expressing colon cancer cells (EC50 = 8.38 µM); induces p53 mutant protein degradation via MDM2-mediated ubiquitination

Formal name: 1-(4-methyl-1-piperazinyl)-3-(5-nitro-2-furanyl)-2-propen-1-one

Synonyms: 

Molecular weight: 265.3

CAS: 803647-40-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System

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