A potent

CC-223 – 10 mg

Brand:
Cayman
CAS:
1228013-30-6
Storage:
-20
UN-No:
De Minimis - 3077 / 9

CC-223 is a potent inhibitor of mTOR (IC50 = 16 nM) that shows selectivity for mTOR over a panel of 246 other kinases.{33446} It blocks signaling through both mTORC1 and mTORC2, inhibiting the phosphorylation of S6RP, 4EBP1, and Akt(S473) in cellular systems.{33446} CC-223 inhibits growth and induces apoptosis in hematologic and solid tumor cell lines in vitro, and it exhibits dose-dependent tumor growth inhibition in multiple solid tumor xenografts in vivo.{33446}  

 

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SKU: 19917 - Category:

Description

A potent, selective inhibitor of mTOR (IC50 = 16 nM); inhibits growth and induces apoptosis in hematologic and solid tumor cell lines in vitro; inhibits multiple solid tumor xenografts in vivo,

Formal name: 3,4-dihydro-7-[6-(1-hydroxy-1-methylethyl)-3-pyridinyl]-1-(trans-4-methoxycyclohexyl)-pyrazino[2,3-b]pyrazin-2(1H)-one

Synonyms: 

Molecular weight: 397.5

CAS: 1228013-30-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|mTOR||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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