A compound that blocks the interaction of PD-1 with its ligand protein

PD-1/PD-L1 Inhibitor 1 – 5 mg

Brand:
Cayman
CAS:
1675201-83-8
Storage:
-20
UN-No:
Non-Hazardous - /

PD-1/PD-L1 inhibitor 1 is a compound that blocks the interaction of programmed cell death protein 1 (PD-1, CD279) with its ligand protein (PD-L1, CD274). In preliminary studies, PD-1/PD-L1 inhibitor 1 blocks this interaction with an IC50 value between 6 and 100 nM, as assessed by a homogenous time-resolved fluorescence binding assay.{30903} Antibodies that block PD-1/PD-L1 interaction reduce signaling between these co-inhibitory molecules and have shown promise as checkpoint immunomodulators in cancer clinical trials.{31548,31551,31552}  

 

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Description

A compound that blocks the interaction of PD-1 with its ligand protein, PD-L1, with an IC50 value between 6 and 100 nM, as assessed by an HTRF binding assay

Formal name: (2S)-1-[[2,6-dimethoxy-4-[(2-methyl[1,1′-biphenyl]-3-yl)methoxy]phenyl]methyl]-2-piperidinecarboxylic acid

Synonyms:  Programmed Cell Death 1/Programmed Cell Death-Ligand 1 Inhibitor 1

Molecular weight: 475.6

CAS: 1675201-83-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Immunology

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