A selective

Uprosertib – 10 mg

Brand:
Cayman
CAS:
1047634-65-0
Storage:
-20
UN-No:
Non-Hazardous - /

Uprosertib is a selective, orally bioavailable inhibitor of Akt (IC50s = 180, 328, and 38 nM for Akt1, Akt2, and Akt3, respectively).{32165} Uprosertib preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation via PI3K/PTEN mutation or loss.{30969} It can cause cell cycle arrest and consequent tumor growth inhibition in mice bearing either BT474 breast tumor or SK-OV-3 ovarian tumor xenografts.{30969}  

 

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SKU: 19904 - Category:

Description

A selective, orally bioavailable inhibitor of Akt (IC50s = 180, 328, and 38 nM for Akt1, Akt2, and Akt3, respectively); preferentially inhibits the proliferation of human cancer cells lines with Akt pathway activation via PI3K/PTEN mutation or loss

Formal name: N-[(1S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-furancarboxamide

Synonyms:  GSK2141795|GSK795

Molecular weight: 429.2

CAS: 1047634-65-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Activin-like Kinases (ALKs)||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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