An irreversible inhibitor of Glut1 that blocks glucose transport in diverse cancer cells (IC50 = ~0.6 µM) and cancer cell proliferation (IC50s= 5-10 µM); reduces tumor size in mice

WZB117 – 5 mg

Brand:
Cayman
CAS:
1223397-11-2
Storage:
-20
UN-No:
Non-Hazardous - /

WZB117 is an irreversible inhibitor of glucose transporter 1 (Glut1) that blocks glucose transport in diverse cancer cells (IC50 = ~0.6 µM), reducing extracellular lactate and intracellular ATP levels.{32239} It inhibits cancer cell proliferation (IC50s = 5-10 µM), resulting in cell cycle arrest, senescence, and necrosis or apoptosis.{32239,32241} These effects are enhanced by the anticancer drugs cisplatin (Item No. 13119) and paclitaxel (Item No. 10461). WZB117, given intraperitoneally at 10 mg/kg, significantly reduces tumor size in mice, with only small reductions in body weight and leukocyte count.{32239} WZB117 also inhibits the self-renewal and tumor-initiating capacity of cancer stem cells, blocking tumor initiation after implantation of cancer stem cells in mice.{32240}  

 

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Description

An irreversible inhibitor of Glut1 that blocks glucose transport in diverse cancer cells (IC50 = ~0.6 µM) and cancer cell proliferation (IC50s= 5-10 µM); reduces tumor size in mice, with only small reductions in body weight and leukocyte count

Formal name: 3-hydroxy-benzoic acid, (3-fluoro-1,2-phenylene)ester

Synonyms:  Glucose Transporter Inhibitor IV

Molecular weight: 368.3

CAS: 1223397-11-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Cancer Stem Cell Research|Proliferation||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Death|Necrosis||Research Area|Cell Biology|Cell Death|Necrosis||Research Area|Cell Biology|Stem Cell Research|Proliferation||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism

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