A selective inhibitor of TNKS1 and TNKS2 with IC50 values of 3 and 1 nM

AZ 6102 – 1 mg

Brand:
Cayman
CAS:
1645286-75-4
Storage:
-20
UN-No:
Non-Hazardous - /

AZ 6102 is an inhibitor of tankyrases (TNKS) 1 and 2 with IC50 values of 3 and 1 nM, respectively.{32525} It demonstrates 100-fold selectivity for TNKS1/2 over PARP1, PARP2, and PARP6 (IC50s = 2, 0.5, and >3 µM, respectively).{32525} By inhibiting TNKS1/2, AZ6120 has been shown to inhibit Wnt signaling in DLD-1 cells with an IC50 value of 5 nM.{32525}  

 

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Description

A selective inhibitor of TNKS1 and TNKS2 with IC50 values of 3 and 1 nM, respectively; inhibits Wnt signaling in DLD-1 cells with an IC50 value of 5 nM

Formal name: rel-2-[4-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidin-4-one

Synonyms: 

Molecular weight: 428.5

CAS: 1645286-75-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Signaling|Wnt Signaling||Research Area|Cell Biology|Cell Signaling|Wnt Signaling

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