A PRMT5 inhibitor; inhibits the growth of multiple AML cell lines and patient-derived tumor samples (IC50s = 7.21-21.46 and 3.98-8.72 μM

HLCL-61 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
1158279-20-9
Storage:
-20
UN-No:
De Minimis - 3077 / 9

HLCL-61 is an inhibitor of protein arginine methyltransferase 5 (PRMT5) that inhibits the growth of multiple acute myeloid leukemia (AML) cell lines and patient-derived tumor samples (IC50s = 7.21-21.46 and 3.98-8.72 μM, respectively).{38426} It is selective for PRMT5, lacking activity against PRMT1, PRMT4, and PRMT7 in an enzyme assay. HLCL-61 induces myeloid differentiation of THP-1 cells and increases CD11b expression in a dose-dependent manner. It also increases expression of miR-29b mRNA resulting in a 4-fold decrease in FLT3 activity in THP-1 cells expressing an FLT3 luciferase reporter.  

 

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Description

A PRMT5 inhibitor; inhibits the growth of multiple AML cell lines and patient-derived tumor samples (IC50s = 7.21-21.46 and 3.98-8.72 μM, respectively); selective for PRMT5, lacking activity against PRMT1, PRMT4, and PRMT7 in an enzyme assay; induces myeloid differentiation of THP-1 cells and increases CD11b expression in a dose-dependent manner; increases expression of miR-29b mRNA resulting in a 4-fold decrease in FLT3 activity in THP-1 cells expressing an FLT3 luciferase reporter,

Formal name: 9-ethyl-N-[(2-methoxyphenyl)methyl]-9H-carbazole-3-methanamine, monohydrochloride

Synonyms: 

Molecular weight: 380.9

CAS: 1158279-20-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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