An alkaloid with diverse biological activities; induces autophagy in HeLa

Tetrandrine – 250 mg

Brand:
Cayman
CAS:
518-34-3
Storage:
-20
UN-No:
Non-Hazardous - /

Tetrandrine is a bis-benzylisoquinoline alkaloid that has been found in R. stephania roots and has diverse biological activities.{32196,32195,32197,32194} It induces autophagy in HeLa, MCF-7, and human foreskin fibroblast (HFF) cells when used at a concentration of 5 µM, an effect that can be reversed by the autophagy inhibitor 3-methyladenine (Item No. 13242).{32196} Tetrandrine inhibits PAF-, thrombin-, collagen-, ADP-, or epinephrine-induced aggregation of isolated human platelets.{32195} Priming of mesenchymal stem cells (MSCs) with tetrandrine (5 and 10 µM) reduces TNF-α secretion by RAW 264.7 cells in co-culture.{32197} Ear skin transplantation of tetrandrine-primed MSCs decreases ear levels of TNF-α in a mouse model of ear skin inflammation. Tetrandrine (1 mg/kg) increases soleus muscle levels of glucose transporter 4 (Glut4) and decreases plasma glucose levels in a rat model of diabetes induced by streptozotocin (Item No. 13104).{32194}  

 

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Description

An alkaloid with diverse biological activities; induces autophagy in HeLa, MCF-7, and HFF cells at 5 µM; inhibits PAF-, thrombin-, collagen-, ADP-, or epinephrine-induced aggregation of isolated human platelets; priming of MSCs at 5 and 10 µM reduces TNF-α secretion by RAW 264.7 cells in co-culture; ear skin transplantation of primed MSCs decreases ear levels of TNF-α in a mouse model of ear skin inflammation; increases soleus muscle levels of Glut4 and and decreases plasma glucose levels in a rat model of streptozotocin-induced diabetes

Formal name: (4aS,16aS)-3,4,4a,5,16a,17,18,19-octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2′,3′:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline

Synonyms:  (S,S)-(+)-Tetrandrine|d-Tetrandrine|NSC 77037

Molecular weight: 622.8

CAS: 518-34-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cancer|Autophagy||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Cell Biology|Stem Cell Research||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity

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