A chalcone and flavonoid with diverse biological activities; active against C. albicans and C. neoformans (IC50s = 3 and 7 µg/ml

Isobavachalcone – 50 mg

Brand:
Cayman
CAS:
20784-50-3
Storage:
-20
UN-No:
Non-Hazardous - /

Isobavachalcone (IBC) is a chalcone and flavonoid originally isolated from P. corylifolia and has diverse biological activities.{31777,53967} It is active against C. albicans and C. neoformans (IC50s = 3 and 7 µg/ml, respectively), as well as T. rubrum and M. audouinii (MIC = 1.2 µg/ml for both).{31777} IBC is active against various Bacillus, Streptococcus, and Proteus species, as well as K. pneumoniae, P. aeruginosa, S. typhi, M. morganii, E. aerogenes, C. freundii, and E. cloacae (MICs = 4.9-39.1 µg/ml). It induces mitochondrial-mediated apoptosis in IMR-32 and NB-39 human neuroblastoma cells and inhibits the proliferation of OVCAR-8 ovarian, PC3 prostate, MCF-7 breast, and A549 lung cancer cell lines. IBC (50 mg/kg) reduces dopaminergic neuronal cell death and increases the stay time in the rotarod test in a mouse model of MPTP-induced Parkinson’s disease.{53967}  

 

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Description

A chalcone and flavonoid with diverse biological activities; active against C. albicans and C. neoformans (IC50s = 3 and 7 µg/ml, respectively), as well as T. rubrum and M. audouinii (MIC = 1.2 µg/ml for both); active against various bacteria (MICs = 4.9-39.1 µg/ml); induces mitochondrial-mediated apoptosis in IMR-32 and NB-39 human neuroblastoma cells; inhibits the proliferation of OVCAR-8 ovarian, PC3 prostate, MCF-7 breast, and A549 lung cancer cell lines; reduces dopaminergic neuronal cell death and increases the stay time in the rotarod test in a mouse model of MPTP-induced Parkinson’s disease at 50 mg/kg

Formal name: (2E)-1-[2,4-dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one

Synonyms:  Corylifolinin|IBC

Molecular weight: 324.4

CAS: 20784-50-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Chalcones||Product Type|Biochemicals|Natural Products|Flavonoids||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia||Research Area|Infectious Disease|Bacterial Diseases|Typhoid||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Neuroscience|Neuroprotection

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