Description
A chalcone and flavonoid with diverse biological activities; active against C. albicans and C. neoformans (IC50s = 3 and 7 µg/ml, respectively), as well as T. rubrum and M. audouinii (MIC = 1.2 µg/ml for both); active against various bacteria (MICs = 4.9-39.1 µg/ml); induces mitochondrial-mediated apoptosis in IMR-32 and NB-39 human neuroblastoma cells; inhibits the proliferation of OVCAR-8 ovarian, PC3 prostate, MCF-7 breast, and A549 lung cancer cell lines; reduces dopaminergic neuronal cell death and increases the stay time in the rotarod test in a mouse model of MPTP-induced Parkinson’s disease at 50 mg/kg
Formal name: (2E)-1-[2,4-dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
Synonyms: Corylifolinin|IBC
Molecular weight: 324.4
CAS: 20784-50-3
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Chalcones||Product Type|Biochemicals|Natural Products|Flavonoids||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia||Research Area|Infectious Disease|Bacterial Diseases|Typhoid||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Neuroscience|Neuroprotection
