An anthraquinone with diverse biological activities; induces necrosis in J5 human liver cancer cells at 25

Chrysophanol – 500 mg

Brand:
Cayman
CAS:
481-74-3
Storage:
-20
UN-No:
Non-Hazardous - /

Chrysophanol is an anthraquinone that has been found in R. palmatum and has diverse biological activities.{31786,31785,31784} It induces necrosis in J5 human liver cancer cells when used at concentrations of 25, 50, 75, 100, and 200 µM.{31785} Chrysophanol (5, 10, and 50 µM) reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) and inhibits LPS-induced DNA oxidation in BV-2 microglia.{31784} In vivo, chrysophanol (5 mg/kg) decreases colonic levels of IL-6 and activation of NF-κB and reduces weight loss, diarrhea, and rectal bleeding in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250).{59380} Chrysophanol (0.1, 1, and 10 mg/kg) increases survival, reduces brain tissue loss, and ameliorates motor balance deficits in a mouse model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{59381}  

 

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Description

An anthraquinone with diverse biological activities; induces necrosis in J5 human liver cancer cells at 25, 50, 75, 100, and 200 µM; reduces LPS-induced production of NO and PGE2 and inhibits LPS-induced DNA oxidation in BV-2 microglia at 5, 10, and 50 µM; decreases colonic levels of IL-6 and activation of NF-κB and reduces weight loss, diarrhea, and rectal bleeding in a mouse model of DSS-induced colitis at 5 mg/kg; increases survival, reduces brain tissue loss, and ameliorates motor balance deficits in a mouse model of MCAO-induced ischemia-reperfusion injury at 0.1, 1, and 10 mg/kg

Formal name: 1,8-dihydroxy-3-methyl-9,10-anthracenedione

Synonyms:  Chrysophanic Acid|NSC 37132|NSC 646567|Turkey Rhubarb

Molecular weight: 254.2

CAS: 481-74-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Anthraquinones||Research Area|Cancer|Cell Death|Necrosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Gastric Disease|Ulcerative Colitis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Neuroscience|Neuroprotection|Ischemia

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