A steroid glycoside with diverse biological activities; reduces SRC-3 protein levels in MCF-7 breast cancer cells from 10-100 nM; reduces Na+/K+ pump activity

Cinobufotalin – 1 mg

Brand:
Cayman
CAS:
1108-68-5
Storage:
-20
UN-No:
- 2811 / 6.1

Cinobufotalin is a steroid glycoside originally isolated from the Asiatic toad (B. gargarizans) and has diverse biological activities.{25457,42765} It reduces SRC-3 protein levels in MCF-7 breast cancer cells when used at concentrations ranging from 10 to 100 nM.{25457} Cinobufotalin (1 μM) reduces Na+/K+ pump activity, viability, and cell attachment of C7-MDCK cells.{42765} It reduces expression of the epithelial-mesenchymal (EMT) markers E-cadherin, vimentin, ZEB1, and Slug in and migration and invasion of PC3 cells.{42766} Cinobufotalin (0.1-10 μM) is cytotoxic to A549, H460, and HTB-58 lung cancer cells.{42767} In vivo, cinobufotalin (1 and 5 mg/kg) reduces tumor volume and increases survival in an A549 mouse xenograft model.  

 

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Description

A steroid glycoside with diverse biological activities; reduces SRC-3 protein levels in MCF-7 breast cancer cells from 10-100 nM; reduces Na+/K+ pump activity, viability, and cell attachment of C7-MDCK cells at 1 μM; reduces expression of EMT markers and migration and invasion of PC3 cells; cytotoxic to A549, H460, and HTB-58 lung cancer cells from 0.1-10 μM; reduces tumor volume and increases survival in an A549 mouse xenograft model at 1 and 5 mg/kg,

Formal name: 16β-(acetyloxy)-14,15β-epoxy-3β,5β-dihydroxy-bufa-20,22-dienolide

Synonyms:  NSC 90326

Molecular weight: 458.6

CAS: 1108-68-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Glycosides||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Cell Migration & Metastasis

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