A flavonoid with diverse biological activities; reduces myocardial apoptosis and increases cardiac microvessel levels of eNOS in a rat model of ischemia-reperfusion injury at 30 and 100 mg/kg; increases the number of intratumor CD8+ T cells and reduces tumor volume in an H22 murine hepatocellular carcinoma model at 50 and 80 mg/kg; reduces LPS-induced cortical production of ROS and levels of IL-1β and TNF-α in a mouse model of neuroinflammation; decreases body weight

Baicalin – 5 g

Brand:
Cayman
CAS:
21967-41-9
Storage:
22
UN-No:
Non-Hazardous - /

Baicalin is a flavonoid that has been found in S. baicalensis and has diverse biological activities.{53853,53854,53855,53857,53856} It reduces myocardial apoptosis and increases cardiac microvessel levels of endothelial nitric oxide synthase (eNOS) in a rat model of ischemia-reperfusion injury when administered at doses of 30 and 100 mg/kg. Baicalin (50 and 80 mg/kg) increases the number of intratumor CD8+ T cells and reduces tumor volume in an H22 murine hepatocellular carcinoma model.{53854} It reduces LPS-induced cortical production of reactive oxygen species (ROS) and levels of IL-1β and TNF-α in a mouse model of neuroinflammation.{53855} Baicalin decreases body weight, increases the number of rats with regular estrous cycles, and ameliorates follicular development in a mouse model of dehydroepiandrosterone-induced polycystic ovary syndrome (PCOS).{53857} It also decreases immobility time in the forced swim test in a mouse model of depression induced by chronic mild stress.{53856}  

 

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Description

A flavonoid with diverse biological activities; reduces myocardial apoptosis and increases cardiac microvessel levels of eNOS in a rat model of ischemia-reperfusion injury at 30 and 100 mg/kg; increases the number of intratumor CD8+ T cells and reduces tumor volume in an H22 murine hepatocellular carcinoma model at 50 and 80 mg/kg; reduces LPS-induced cortical production of ROS and levels of IL-1β and TNF-α in a mouse model of neuroinflammation; decreases body weight, increases the number of rats with regular estrous cycles, and ameliorates follicular development in a mouse model of dehydroepiandrosterone-induced PCOS; decreases immobility time in the forced swim test in a mouse model of depression induced by chronic mild stress

Formal name: 5,6-dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl-β-D-glucopyranosiduronic acid

Synonyms:  Baicalein 7-glucuronide

Molecular weight: 446.4

CAS: 21967-41-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Immunology||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Vasculature||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Nitrogen|eNOS||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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