Description
An inhibitor of interactions between the transcription co-activator Mediator complex and the CgPdr1 transcription factor in the pathogen C. glabrata; inhibits the interaction between the KIX domain of the Mediator subunit CgGal11A and the activation domain of CgPdr1 (IC50 = 190.2 μM); inhibits ketoconazole-induced expression of CgPdr1-target genes involved in multidrug resistance and drug efflux in C. glabrata at 10 and 30 μM; increases the sensitivity of azole-resistant C. glabrata strains expressing CgPDR1 gain-of-function mutations to fluconazole and ketoconazole; decreases fungal burden in the kidney and spleen in a mouse model of infection with azole-sensitive or -resistant C. glabrata at 100 mg/kg when administered in combination with low and high doses of fluconazole, respectively
Formal name: 2-cyano-acetic acid, 2-[[(3,4-dichlorophenyl)amino]thioxomethyl]hydrazide
Synonyms:
Molecular weight: 303.2
CAS: 656222-54-7
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Candidiasis
