A neprilysin inhibitor (IC50 = 5 nM); selective for neprilysin over ACE at 10 μM; inhibits neprilysin cleavage of enkephalin

LBQ657 – 5 mg

Brand:
Cayman
CAS:
149709-44-4
Storage:
-20
UN-No:
Non-Hazardous - /

LBQ657 is an inhibitor of neprilysin (IC50 = 5 nM).{42277} It is selective for neprilysin over angiotensin converting enzyme (ACE) when used at a concentration of 10 μM. LBQ657 inhibits neprilysin cleavage of enkephalin, glutaryl-Ala-Ala-Phe-β-napthylamide, and atrial natriuretic factor (IC50s = 5, 0.74, and 5.3 nM, respectively).  

 

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SKU: 19829 - Category:

Description

A neprilysin inhibitor (IC50 = 5 nM); selective for neprilysin over ACE at 10 μM; inhibits neprilysin cleavage of enkephalin, glutaryl-Ala-Ala-Phe-β-napthylamide, and atrial natriuretic factor (IC50s = 5, 0.74, and 5.3 nM, respectively),

Formal name: γS-[(3-carboxy-1-oxopropyl)amino]-αR-methyl-[1,1′-biphenyl]-4-pentanoic acid

Synonyms:  Sacubitrilat

Molecular weight: 383.4

CAS: 149709-44-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area

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