A fluorescent affinity probe for amyloid-β with ex./em. spectra of 498/578 nm

CRANAD 28 – 1 mg

Brand:
Cayman
CAS:
1623747-97-6
Storage:
-20
UN-No:
Non-Hazardous - /

CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo that has excitation/emission spectra of 498/578 nm, respectively.{40278} It binds to various forms of Aβ, including Aβ40 monomers and aggregates, as well as Aβ42 monomers, dimers, and oligomers (Kds = 68.8, 52.4, 159.7, 162.9, and 85.7 nM, respectively). When bound to Aβ, the fluorescence intensity decreases, in contrast to similar curcumin-based fluorescent probes. CRANAD 28 labels amyloid plaques and cerebral amyloid angiopathy both in APP/PS1 mouse brain sections and in live mice following i.v. administration. It also inhibits copper-induced and naturally occurring Aβ crosslinking.  

 

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SKU: 19816 - Category:

Description

A fluorescent affinity probe for amyloid-β with ex./em. spectra of 498/578 nm, respectively; binds to Aβ40 monomers and aggregates, as well as Aβ42 monomers, dimers, and oligomers (Kds = 68.8, 52.4, 159.7, 162.9, and 85.7 nM, respectively); fluorescence decreases when bound; labels amyloid plaques and cerebral amyloid angiopathy both in APP/PS1 mouse brain sections and in live mice following i.v. administration; inhibits copper-induced and naturally occurring Aβ crosslinking ,

Formal name:

Synonyms: 

Molecular weight: 484.3

CAS: 1623747-97-6

Purity: ≥98%

Formulation: A crystalline solid

Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Affinity Probes||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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