A synthetic β-lactam antibiotic of the monobactam class; active against clinical isolates of E. coli

Aztreonam – 50 mg

Brand:
Cayman
CAS:
78110-38-0
Storage:
-20
UN-No:
Non-Hazardous - /

Aztreonam is a synthetic β-lactam antibiotic of the monobactam class.{31705} It is active against clinical isolates of E. coli, S. marcescens, P. aeruginosa, Klebsiella species, Proteus species, and Enterobacter species (MICs = S. pneumoniae, B. fragilis, and S. faecalis (MICs = >100 µg/ml for all). It interferes with peptidoglycan synthesis in the bacterial cell wall of the Gram-negative bacteria E. coli, P. vulgaris, E. cloacae, K. pneumoniae, and P. aeruginosa by inhibiting penicillin-binding protein 3 (PBP3; IC100 = 0.1 µg/ml for all). It increases survival in mice with systemic Gram-negative bacterial infections (ED50s = 0.1-24.7 mg/kg). Formulations containing aztreonam have been used in the treatment of P. aeruginosa infections in individuals with cystic fibrosis.  

 

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Description

A synthetic β-lactam antibiotic of the monobactam class; active against clinical isolates of E. coli, S. marcescens, P. aeruginosa, Klebsiella species, Proteus species, and Enterobacter species (MICs = S. pneumoniae, B. fragilis, and S. faecalis (MICs = >100 µg/ml for all); interferes with peptidoglycan synthesis in the bacterial cell wall of the Gram-negative bacteria E. coli, P. vulgaris, E. cloacae, K. pneumoniae, and P. aeruginosa by inhibiting penicillin-binding protein 3 (PBP3; IC100 = 0.1 µg/ml for all); increases survival in mice with systemic Gram-negative bacterial infections (ED50s = 0.1-24.7 mg/kg)

Formal name: 2-[[(Z)-[1-(2-amino-4-thiazolyl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-2-methyl-propanoic acid

Synonyms:  SQ 26,776

Molecular weight: 435.4

CAS: 78110-38-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Monobactams||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Pulmonary Diseases||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia

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