An orally available PARP1 and PARP2 inhibitor (Kis = 1.2 and 0.85 nM

BMN 673 – 5 mg

Brand:
Cayman
CAS:
1207456-01-6
Storage:
-20
UN-No:
Non-Hazardous - /

BMN 673 is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor with an IC50 value of 0.57 nM.{32032} It similarly binds to PARP1 and PARP2 with Ki values of 1.2 and 0.85 nM, respectively, but has no effect on PARG.{32032} BMN 673 selectively targets tumor cells with BRCA1, BRCA2, or PTEN gene mutations and elicits antitumor activity in xenografted tumors in mice.{32032}  

 

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Description

An orally available PARP1 and PARP2 inhibitor (Kis = 1.2 and 0.85 nM, respectively); selectively targets tumor cells with BRCA1, BRCA2, or PTEN gene mutations and elicits antitumor activity in xenografted tumors

Formal name: (8S,9R)-5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3H-pyrido[4,3,2-de]phthalazin-3-one

Synonyms:  Talazoparib

Molecular weight: 380.4

CAS: 1207456-01-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|DNA Repair Enzymes||Research Area|Cancer|DNA Damage and Repair|PARP

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