An orally bioavailable inhibitor of ALK (IC50 < 100 nM in Ba/F3 cells); a pan-ALK inhibitor that also inhibits several ALK mutants that confer resistance to other ALK inhibitors

AP26113 – 1 mg

Brand:
Cayman
CAS:
1197953-54-0
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

AP26113 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK; IC50 12087), ceritinib (Item No. 19374), and CH5424802 (Item No. 18516).{31962,31296} AP26113 blocks ALK activity and reduces growth in neuroblastoma cells, mouse xenograft, and Drosophila model systems harboring constitutively active ALK variants.{31963}  

 

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Description

An orally bioavailable inhibitor of ALK (IC50 < 100 nM in Ba/F3 cells); a pan-ALK inhibitor that also inhibits several ALK mutants that confer resistance to other ALK inhibitors

Formal name: 5-chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4-pyrimidinediamine

Synonyms:  Brigatinib

Molecular weight: 584.1

CAS: 1197953-54-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling

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