A cell-permeable

Inauhzin – 10 mg

Brand:
Cayman
CAS:
309271-94-1
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Inauhzin is a cell-permeable, SIRT1 inhibitor (IC50 = 0.7-2 µM) that reactivates p53 by inhibiting SIRT1 deacetylation activity.{31611} It binds directly to SIRT1 and does not affect SIRT2, SIRT3, or HDAC8.{31611} Inauhzin has been shown to inhibit cell proliferation by inducing p53-dependent apoptosis in various human cancer cells (IC50s = 5.4, 51.9, 3.2, 33.9, and 85.4 µM for H460, H1299, A549, HT-29, and WI38 cells, respectively), as well as in xenograft tumors derived from H460 cells.{31611} It has also been shown to activate p53 synergistically with the Mdm2 inhibitor nutlin-3 (Item No. 10004372), sensitizing cancer cells to cisplatin (Item No. 13119) and doxorubicin (Item No. 15007).{31610}  

 

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Description

A cell-permeable, selective SIRT1 inhibitor (IC50 = 0.7-2 µM) that reactivates p53 by inhibiting SIRT1 deacetylation activity; inhibits cell proliferation by inducing p53-dependent apoptosis in various human cancer cells (IC50s = 5.4, 51.9, 3.2, 33.9, and 85.4 µM for H460, H1299, A549, HT-29, and WI38 cells, respectively), as well as in xenograft tumors

Formal name: 1-(10H-phenothiazin-10-yl)-2-(5H-1,2,4-triazino[5,6-b]indol-3-ylthio)-1-butanone

Synonyms: 

Molecular weight: 469.6

CAS: 309271-94-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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