An atypical antipsychotic; binds to α1- and α2-adrenergic and dopamine D2 receptors (Kds = 180

Melperone (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
1622-79-3
Storage:
-20
UN-No:
Non-Hazardous - /

Melperone is an atypical antipsychotic.{25511} It binds to α1- and α2-adrenergic and dopamine D2 receptors (Kds = 180, 150, and 180 nM, respectively), as well as the serotonin (5-HT) receptor subtype 5-HT2A (Kd = 102 nM). It is selective for these receptors over histamine H1, muscarinic, 5-HT1A, 5-HT1D, and 5-HT2C receptors (Kds = 580, >10,000, 2,200, 3,400, and 2,100 nM, respectively). Melperone (2 mg/kg per day) increases basal, but not amphetamine-induced, extracellular dopamine levels in the rat nucleus accumbens.{53986}  

 

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Description

An atypical antipsychotic; binds to α1- and α2-adrenergic and dopamine D2 receptors (Kds = 180, 150, and 180 nM, respectively), as well as 5-HT2A (Kd = 102 nM); selective for these receptors over histamine H1, muscarinic, 5-HT1A, 5-HT1D, and 5-HT2C receptors (Kds = 580, >10,000, 2,200, 3,400, and 2,100 nM, respectively); increases basal extracellular dopamine levels in the rat nucleus accumbens at 2 mg/kg per day

Formal name: 1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone, monohydrochloride

Synonyms:  FG 5111|Methylperone

Molecular weight: 299.8

CAS: 1622-79-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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