An inhibitor of URAT1 (IC50 = 0.3 µM for hURAT1) that prevents renal urate resorption; also potently inhibits CYP2C9 (Ki = 20 nM) and has been used to study adverse drug-drug interactions

Benzbromarone – 1 g

Brand:
Cayman
CAS:
3562-84-3
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

Benzbromarone is an inhibitor of the urate anion transporter (IC50 = 0.3 µM for hURAT1) that prevents renal urate resorption.{31716} It also potently inhibits CYP2C9 (Ki = 20 nM), a major cytochrome P450 enzyme involved in the metabolic clearance of a wide range of therapeutic agents.{24422} Several analogs of benzabromarone have been developed with varying binding affinities to CYP2C9 in order to study adverse drug-drug interactions.{24411}  

 

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Description

An inhibitor of URAT1 (IC50 = 0.3 µM for hURAT1) that prevents renal urate resorption; also potently inhibits CYP2C9 (Ki = 20 nM) and has been used to study adverse drug-drug interactions

Formal name: (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-3-benzofuranyl)-methanone

Synonyms:  MJ10061|NSC 85433

Molecular weight: 424.1

CAS: 3562-84-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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