Sakuranetin – 10 mg

Brand:
Cayman
CAS:
520-29-6
Storage:
-20
UN-No:
Non-Hazardous - /

Sakuranetin is a flavonoid and phytoalexin that has been found in rice and has diverse biological activities.{34183,53873,34186,34182} It reduces blast fungus mycelium growth in vitro and decreases the number of fungal lesions and fungal DNA in blast fungus-infected rice leaves when applied at concentrations of 0.1 and 0.2 mM.{34183} Sakuranetin is active against M. luteus and B. subtilis (MICs = 2 and 0.5 µg/ml, respectively).{53873} It is cytotoxic to KB nasopharyngal carcinoma cells (EC50 = 10 µg/ml). Sakuranetin (20 mg/kg) reduces alveolar enlargement, collagen and elastic fiber deposition, and bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-1β, and M-CSF in a mouse model of elastase-induced emphysema.{34186} It also reduces collagen fiber deposition and lung inflammation in a mouse model of LPS-induced acute lung injury.{34182}  

 

Available on backorder

SKU: 19761 - Category:

Description

A flavonoid with diverse biological activities; reduces blast fungus mycelium growth in vitro and decreases the number of fungal lesions and fungal DNA in blast fungus-infected rice leaves at 0.1 and 0.2 mM; active against M. luteus and B. subtilis (MICs = 2 and 0.5 µg/ml, respectively); cytotoxic to KB nasopharyngal carcinoma cells (EC50 = 10 µg/ml); reduces alveolar enlargement, collagen and elastic fiber deposition, and BALF levels of TNF-α, IL-1β, and M-CSF in a mouse model of elastase-induced emphysema at 20 mg/kg; reduces collagen fiber deposition and lung inflammation in a mouse model of LPS-induced acute lung injury


Formal name: 2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 286.3

CAS: 520-29-6

Purity: ≥98%

Formulation: A crystalline solid


Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Pesticides|Fungicides||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Plant Biology|Plant Defense