Description
An inhibitor of PHD2 (IC50 = 2 μM in a reporter assay using SH-SY5Y-ODD-Luc cells); stabilizes HIF-1α protein and induces expression of EPO and VEGF in SH-SY5Y human neuroblastoma cells; protects against glutathione depletion-induced cell death in rat primary cortical neurons (IC50 = 0.25 μM); reduces glutamate-induced cell death in HT-22 cells; increases pellet retrieval in the single-pellet reaching task in a a rat autologous striatal blood infusion model of intracerebral hemmorhage and normalizes preference for ipsilateral turns in a mouse model of striatal hemorrhage at 30 mg/kg
Formal name: 7-[(4-chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol
Synonyms:
Molecular weight: 377.8
CAS: 385786-48-1
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Neuroscience|Neuroprotection||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione
