A PHGDH inhibitor that blocks serine synthesis from 3-phosphoglycerate in cells (IC50 = 2.5 µM); reduces the production of glucose-derived serine in cells and suppresses the growth of PHGDH-dependent MDA-MB-468 cancer cells both in vitro and in mice bearing orthotopic xenograft tumors

NCT-503 – 5 mg

Brand:
Cayman
CAS:
1916571-90-8
Storage:
-20
UN-No:
Non-Hazardous - /

NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 2.5 µM.{31375} It has been shown to reduce the production of glucose-derived serine in cells and to suppress the growth of PHGDH-dependent MDA-MB-468 cancer cells both in vitro and in mice bearing orthotopic xenograft tumors.{31375}  

 

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Description

A PHGDH inhibitor that blocks serine synthesis from 3-phosphoglycerate in cells (IC50 = 2.5 µM); reduces the production of glucose-derived serine in cells and suppresses the growth of PHGDH-dependent MDA-MB-468 cancer cells both in vitro and in mice bearing orthotopic xenograft tumors

Formal name: N-(4,6-dimethyl-2-pyridinyl)-4-[[4-(trifluoromethyl)phenyl]methyl]-1-piperazinecarbothioamide

Synonyms: 

Molecular weight: 408.5

CAS: 1916571-90-8

Purity: ≥98%

Formulation: A neat solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer

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