A reversible inhibitor of Tpl2 (pIC50 = 7.3); blocks LPS-induced TNF-α production in mice and human monocytes

Tpl2 Kinase Inhibitor – 25 mg

Brand:
Cayman
CAS:
871307-18-5
Storage:
-20
UN-No:
Non-Hazardous - /

Tpl2 kinase inhibitor is a reversible inhibitor of tumor progression locus 2 (Tpl2; pIC50 = 7.3).{32782} It blocks LPS-induced TNF-α production in mice and human monocytes.{32782,32783} Tpl2 kinase inhibitor has been used to evaluate the role of this enzyme in the proliferation and differentiation of cancer cells.{32784,32785}  

 

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Description

A reversible inhibitor of Tpl2 (pIC50 = 7.3); blocks LPS-induced TNF-α production in mice and human monocytes

Formal name: 4-[(3-chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

Synonyms:  c-Cot Kinase Inhibitor|MAP3K8 Kinase Inhibitor|Tumor Progression Locus 2 Kinase Inhibitor

Molecular weight: 404.8

CAS: 871307-18-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling

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