A selective LSD1 inhibitor (Ki(inact) = 59 nM); induces bulk histone H3K4me2 in LNCaP cancer cells (EC50 = ~2 µM) and protects neurons exposed to oxidative stress

Bizine – 1 mg

Brand:
Cayman
CAS:
1591932-50-1
Storage:
-20
UN-No:
Non-Hazardous - /

Bizine is a phenelzine analog that inhibits lysine-specific demethylase 1 (LSD1; Ki(inact) = 59 nM).{32531} It is 23-fold, 63-fold, and >100-fold selective for LSD-1 over monoamine oxidase (MAO) A, MAOB, and LSD2, respectively.{32531} Bizine has been shown to induce bulk histone H3 lysine 4 dimethylation in LNCaP cancer cells (EC50 = ~2 µM) and, at 0.5 µM, to protect neurons exposed to oxidative stress.{32531}  

 

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Description

A selective LSD1 inhibitor (Ki(inact) = 59 nM); induces bulk histone H3K4me2 in LNCaP cancer cells (EC50 = ~2 µM) and protects neurons exposed to oxidative stress

Formal name: N-[4-(2-hydrazinylethyl)phenyl]-benzenebutanamide

Synonyms: 

Molecular weight: 297.4

CAS: 1591932-50-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Demethylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Neuroscience|Neuroprotection

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