A vasopressin V2 receptor antagonist (IC50 = 3 nM for rat receptor); selective for V2 over V1 receptors (IC50 = 0.58 μM); increases urine volume by 3-fold in rats at 0.54 mg/kg; reduces left ventricular end-systolic volumes and improves left ventricular ejection fraction in a rat model of myocardial infarction

Tolvaptan – 5 mg

Brand:
Cayman
CAS:
150683-30-0
Storage:
-20
UN-No:
Non-Hazardous - /

Tolvaptan is a nonpeptide vasopressin V2 receptor antagonist (IC50 = 3 nM for rat receptor) and a diuretic agent.{31703} It is selective for V2 over V1 receptors (IC50 = 0.58 μM). Tolvaptan increases urine volume by 3-fold in rats when administered at a dose of 0.54 mg/kg. It also reduces left ventricular end-systolic volumes and improves left ventricular ejection fraction in a rat model of myocardial infarction.{43556} Formulations containing tolvaptan have been used to treat hyponatremia.  

 

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Description

A vasopressin V2 receptor antagonist (IC50 = 3 nM for rat receptor); selective for V2 over V1 receptors (IC50 = 0.58 μM); increases urine volume by 3-fold in rats at 0.54 mg/kg; reduces left ventricular end-systolic volumes and improves left ventricular ejection fraction in a rat model of myocardial infarction

Formal name: N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methyl-benzamide

Synonyms:  OPC 41061

Molecular weight: 448.9

CAS: 150683-30-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Endocrinology & Metabolism|Hormones & Receptors

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