A specific antagonist of the type 4 PGE2 receptor EP4; possesses significant anti-tumor growth activity in multiple preclinical tumor models through modulating myeloid cells

E7046 – 50 mg

Brand:
Cayman
CAS:
1369489-71-3
Storage:
-20
UN-No:
Non-Hazardous - /

E7046 is a specific antagonist of the type 4 prostaglandin E2 (PGE2) receptor EP4. It possesses significant antitumor growth activity in multiple preclinical tumor models through modulating myeloid cells, including tumor-associated macrophages and myeloid-derived suppressor cells.{31905} E7046 is being evaluated in cancer models and clinical trials, alone or in combination with other immunotherapeutic compounds.{31904,31906}  

 

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Description

A specific antagonist of the type 4 PGE2 receptor EP4; possesses significant anti-tumor growth activity in multiple preclinical tumor models through modulating myeloid cells

Formal name: 4-[(1S)-1-[[[3-(difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]-1H-pyrazol-4-yl]carbonyl]amino]ethyl]-benzoic acid

Synonyms: 

Molecular weight: 483.4

CAS: 1369489-71-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer||Research Area|Immunology & Inflammation|Immunotherapeutics||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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