A natural chalcone that induces apoptosis in prostate cancer cell lines (IC50s = 32

Flavokawain B – 500 µg

Brand:
Cayman
CAS:
1775-97-9
Storage:
-20
UN-No:
Non-Hazardous - /

Flavokawain B is a natural chalcone first isolated from extracts of kava roots. It induces apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50s = 32, 48, 6.2, and 3.9 µM for LAPC4, LNCaP, PC-3, and DU145 cells, respectively, treated for 48 hours), with increased expression of the proapoptotic protein Bim.{31388} Flavokawain B increases Bim expression and inhibits growth of DU145 xenografts in mice.{31388} It also increases Bim expression, promotes apoptosis, and induces cell cycle arrest in uterine leiomyosarcoma cells.{31387} However, flavokawain B is hepatotoxic, triggering oxidative stress, inhibiting NF-κB signaling, and activating MAPK pathways, culminating in HepG2 and L-02 cell death (LD50s = 15 and 32 µM, respectively).{31389}  

 

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Description

A natural chalcone that induces apoptosis in prostate cancer cell lines (IC50s = 32, 48, 6.2, and 3.9 µM for LAPC4, LNCaP, PC-3, and DU145 cells, respectively, treated for 48 hours); increases Bim expression and inhibits growth of DU145 xenografts in mice; hepatotoxic

Formal name: (2E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-2-propen-1-one

Synonyms: 

Molecular weight: 284.3

CAS: 1775-97-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Chalcones||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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