A selective β3-adrenergic receptor antagonist (Ki = 4 nM); inhibits agonist-stimulated lipolysis in rhesus monkey adipocytes

L-748,337 – 10 mg

Brand:
Cayman
CAS:
244192-94-7
Storage:
-20
UN-No:
Non-Hazardous - /

L-748,337 is a β3-adrenergic receptor antagonist that displays selectivity over β1 and β2 receptors (Kis = 4, 390, and 204 nM, respectively).{32649} It has been shown to couple with Gi to activate MAPK signaling.{30080} L-748,337 can inhibit agonist-stimulated lipolysis in rhesus monkey adipocytes, as well as agonist-induced relaxation of smooth muscle.{32649}  

 

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Description

A selective β3-adrenergic receptor antagonist (Ki = 4 nM); inhibits agonist-stimulated lipolysis in rhesus monkey adipocytes, as well as agonist-induced relaxation of smooth muscle

Formal name: N-[[3-[(2S)-2-hydroxy-3-[[2-[4-[(phenylsulfonyl)amino]phenyl]ethyl]amino]propoxy]phenyl]methyl]-acetamide

Synonyms: 

Molecular weight: 497.6

CAS: 244192-94-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases||Research Area|Cardiovascular System|Heart|Arrhythmia

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