A reversible thrombin inhibitor (IC50s = 0.01 and 0.09 µM for the free and clot-bound forms

Argatroban – 5 mg

Brand:
Cayman
CAS:
74863-84-6
Storage:
-20
UN-No:
Non-Hazardous - /

Argatroban is a reversible inhibitor of thrombin (IC50s = 0.01 and 0.09 µM for the free and clot-bound forms, respectively).{31477} It is selective for thrombin over factor Xa, trypsin, plasmin, and tissue plasminogen activator (Kis = 0.0045, 53, 0.19, 25.7, and 87.7 µM, respectively). It inhibits thrombin-induced platelet aggregation in washed isolated guinea pig platelets with an IC50 value of 0.077 µM.{54177} Argatroban (3.2 mg/kg, s.c.) decreases thrombus formation in a guinea pig model of iron chloride-induced arterial thrombosis. Formulations containing argatroban have been used in the prevention or treatment of thrombosis in patients with heparin-induced thrombocytopenia.  

 

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SKU: 19639 - Category:

Description

A reversible thrombin inhibitor (IC50s = 0.01 and 0.09 µM for the free and clot-bound forms, respectively); selective for thrombin over factor Xa, trypsin, plasmin, and tissue plasminogen activator (Kis = 0.0045, 53, 0.19, 25.7, and 87.7 µM, respectively); inhibits thrombin-induced platelet aggregation in washed isolated guinea pig platelets (IC50 = 0.077 µM); decreases thrombus formation in a guinea pig model of iron chloride-induced arterial thrombosis at 3.2 mg/kg

Formal name: (2R,4R)-1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid

Synonyms:  MCI-9038

Molecular weight: 508.6

CAS: 74863-84-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Blood Coagulation Factors||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis

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