An isothiocyanate with diverse biological activities; inhibits NO production in mouse peritoneal exudate macrophages at 5 µM; inhibits arachidonic acid-induced aggregation of isolated human platelets (IC50 = 21.9 µM); reduces cell survival in a panel of breast

6-Methylsulfinylhexyl Isothiocyanate – 5 mg

Brand:
Cayman
CAS:
4430-35-7
Storage:
-20
UN-No:
Non-Hazardous - 1170 / 3

6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is an isothiocyanate that has been found in wasabi (W. japonica) and has diverse biological activities.{31411,31409,54330,31410,54331} It inhibits nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at a concentration of 5 µM.{31411} It inhibits aggregation of isolated human platelets induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607; IC50 = 21.9 µM).{31409} 6-MSITC reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC50 = 43.7 µM).{54330} In vivo, 6-MSITC (5 mg/kg twice weekly) reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of Parkinson’s disease induced by 6-OHDA (Item No. 25330).{31410} 6-MSITC also reduces the number of lung metastases in a B16/F10 murine melanoma model.{54331}  

 

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Description

An isothiocyanate with diverse biological activities; inhibits NO production in mouse peritoneal exudate macrophages at 5 µM; inhibits arachidonic acid-induced aggregation of isolated human platelets (IC50 = 21.9 µM); reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC50 = 43.7 µM); reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of 6-OHDA-induced Parkinson’s disease at 5 mg/kg twice weekly; reduces the number of lung metastases in a B16/F10 murine melanoma model

Formal name: 1-isothiocyanato-6-(methylsulfinyl)-hexane

Synonyms:  6-MSITC

Molecular weight: 205.3

CAS: 4430-35-7

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Natural Products|Isothiocyanates||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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